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3D bioprinting of functional meniscus constructs with anisotropic properties using meniscus-derived bioink for knee meniscus regeneration.
Weekend observation (25 July 2026, Asia/Shanghai): no usable routine new-paper batch was visible. This issue only summarizes the latest visible PubMed Date-Publication records from 2026-07-24 (24 July 2026); their source date is not a new-publication claim for the observation date.
Meniscal injuries frequently result in progressive degeneration of the knee joint, primarily due to the tissue's limited intrinsic healing capacity. To address this clinical challenge, we developed an anisotropic meniscus scaffold using three-dimensional (3D) bioprinting technology to promote functional regeneration. In this study, the scaffold was fabricated via 3D bioprinting, employing a composite of polyurethane and polycaprolactone polymers, meniscus derived decellularized extracellular matrix bioink, and mesenchymal stem cells (MSCs).In vitro, the bioprinted constructs, incorporating tissue-derived bioinks with region-specific stiffness, facilitated the differentiation of MSCs and extracellular matrix deposition in a manner that recapitulated the native anisotropic architecture of the meniscus.In vivo, the constructs demonstrated excellent chondroprotective effects and supported neo-meniscus formation in a canine model at 12 and 24 weeks post-implantation. These findings suggest that the engineered 3D bioprinted meniscus scaffold holds strong potential for clinical application in meniscal repair and regeneration.
Evidence boundary: 这是一项体外与犬模型研究，不是人体临床试验；聚合物支架只有在结合细胞与组织工程目标时才纳入本栏。